Ammonium Hydroxide → HCID 68535478, compound

Participants

Reaction Steps

Ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate (2.1 g, 4.2 mmol) was taken up in THF (30 ml), and NH4OH (25% (w/v) in H2O, 20 ml) was added. The mixture was stirred at room temperature for 12 h and then concentrated on a rotary evaporator. The residue obtained in this manner was purified by column chromatography (SiO2, hexane/ethyl acetate). This gave 0.4 g (21%) of a non-polar isomer and 0.6 g (31%) of a polar isomer.

Provenance & Evidence