Ammonium Chloride → HCID 86761860, compound

Participants

Reaction Steps

At 0° C., tetrabutylammonium fluoride (1 mM in THF, 0.5 ml, 0.5 mmol) was added dropwise to 3-benzyl-1,4-dimethyl-6-(2-trimethylsilanylethynylbenzyl)piperazine-2,5-dione (140 mg, 0.22 mmol) in THF (abs., 5 ml). The mixture was stirred at this temperature for 1 h. After addition of NH4Cl solution (saturated, aq.), the mixture was extracted with ethyl acetate and the organic phases were dried and concentrated. Purification by column chromatography gave 50 mg (65%) of the target compound as a yellow oil.

Provenance & Evidence