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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2096146Generated: November 1, 2026

1,4-Dioxaspiro[4.5]decan-8-one → 8-(6-Ethoxy-pyridin-3-yl)-1,4-dioxa-spiro[4.5]decan-8-ol

https://huagongshe.com/reaction/2096146

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxaspiro[4.5]decan-8-oneHCID 567415—
Reactant5-Bromo-2-ethoxypyridineHCID 817237—
SolventDiethyl EtherHCID 3283—
Product8-(6-Ethoxy-pyridin-3-yl)-1,4-dioxa-spiro[4.5]decan-8-olHCID 59361578—

Reaction Steps

The title compound was prepared as a white solid from 5-bromo-ethoxy-pyridine (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one in ether using the procedure described in Step A of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08450304B2
Source datasetuspto-grants-2013_05
ORD IDord-7301675b1dca416f89ab69e62edac470
Source noteuspto-grants-2013_05