N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 59361581, compound

HRID 2096151Notes

Reaction equation

HRID 2096151 reaction equation
[CH2:1]([O:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2([OH:22])[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:23]1[CH2:26][CH:25]([NH:27][C:28]([CH2:30][NH:31][C:32](=[O:43])[C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[CH:34]=2)=[O:29])[CH2:24]1>>[CH2:1]([O:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2([OH:22])[CH2:20][CH2:19][CH:18]([N:23]3[CH2:26][CH:25]([NH:27][C:28]([CH2:30][NH:31][C:32](=[O:43])[C:33]4[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:42])([F:40])[F:41])[CH:34]=4)=[O:29])[CH2:24]3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361642HCID 59361642, compound

Product 1

HCID 59361581HCID 59361581, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-(6-benzyloxy-pyridin-3-yl)-4-hydroxy-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-f58cb28669ab49679962e3b7f4364f8b
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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