Potassium tert-butoxide → HCID 46241610, compound

HRID 2096153Notes

Reaction equation

HRID 2096153 reaction equation
F[C:2]1[N:7]=[CH:6][C:5]([C:8]2([OH:35])[CH2:13][CH2:12][CH:11]([N:14]3[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=4)=[O:20])[CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:36][C:37]([O-:40])([CH3:39])[CH3:38].[K+]>>[C:37]([O:40][C:2]1[N:7]=[CH:6][C:5]([C:8]2([OH:35])[CH2:13][CH2:12][CH:11]([N:14]3[CH2:15][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=4)=[O:20])[CH2:17]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1)([CH3:39])([CH3:38])[CH3:36]

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 46241719HCID 46241719, compound

Product 1

HCID 46241610HCID 46241610, compound

Procedure

The title compound was prepared as a white solid from N-({1-[4-(6-fluoro-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide 6a and t-BuOK using the procedure described in Example 8.

Sources & evidence

ORD record
ord-b6839f21b21e43d7a6f0d1db6bf1ebf4
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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