Cyclobutanol → HCID 46241718, compound

HRID 2096155Notes

Reaction equation

F[C:2]1[N:7]=[CH:6][C:5]([C:8]2([OH:35])[CH2:13][CH2:12][CH:11]([N:14]3[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=4)=[O:20])[CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH:36]1([OH:40])[CH2:39][CH2:38][CH2:37]1>>[CH:36]1([O:40][C:2]2[N:7]=[CH:6][C:5]([C:8]3([OH:35])[CH2:13][CH2:12][CH:11]([N:14]4[CH2:15][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]5[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:31])[F:33])[CH:25]=5)=[O:20])[CH2:17]4)[CH2:10][CH2:9]3)=[CH:4][CH:3]=2)[CH2:39][CH2:38][CH2:37]1

Participants

Reactant 2

HCID 76218Cyclobutanol

HCID 46241719HCID 46241719, compound

Product 1

HCID 46241718HCID 46241718, compound

Procedure

The title compound was prepared as a white solid from N-({1-[4-(6-fluoro-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide 6a and cyclobutanol (Aldrich) using the procedure described in Example 8.

Sources & evidence

ORD record: ord-ab46da3bb7954e48a0836a7c56c16220
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08450304B2

Reaction notes

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