Potassium Cyanide → HCID 46241720, compound

Participants

Reaction Steps

N-({1-[4-(6-fluoro-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide 6a (70 mg, 0.14 mmol), KCN (Aldrich, 46 mg, 0.70 mmol) and 18-crown-6 (Aldrich, 190 mg, 0.70 mmol) in DMF (1 mL) were heated to 150° C. in a sealed tube overnight. The reaction solution was loaded on a silica gel column with a CombiFlash® system using ethyl acetate and 7N NH3 in MeOH as eluent (from pure ethyl acetate to 5% 7N NH3 in MeOH in ethyl acetate) to afford the title compound as a white solid.

Provenance & Evidence