HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorobenzoyl chloride → 3,5-Difluoro-N-({1-[4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorobenzoyl chloride | HCID 145600 | — |
| Reactant | 2-amino-N-{1-[4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-acetamide | HCID 59361557 | — |
| Product | 3,5-Difluoro-N-({1-[4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-benzamide | HCID 46241828 | — |
Reaction Steps
The title compound was prepared as yellow solid from coupling of 2-amino-N-{1-[4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-acetamide, as prepared in Step D of Example 16, and 3,5-difluorobenzoyl chloride using the procedure described in Example 18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450304B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e01fb6cf126849b4ad98cdba8997a027 |
| Source note | uspto-grants-2013_05 |