HCID 57803291, compound → HCID 46240378, compound

HRID 2096172Notes

Reaction equation

HRID 2096172 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([OH:15])[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[O:22])[CH2:17]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([OH:15])[CH2:13][CH2:12][CH:11]([N:16]3[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:33])[F:34])[CH:27]=4)=[O:22])[CH2:17]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 57803291HCID 57803291, compoundHCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide

Product 1

HCID 46240378HCID 46240378, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-(5-bromo-pyridin-2-yl)-4-hydroxy-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-779e2532100b4c3aa72da7d1bd3ab8c0
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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