N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46240485, compound

HRID 2096179Notes

Reaction equation

HRID 2096179 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH3:10])[C:6]([C:11]2([OH:18])[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]2)=[CH:5][N:4]=1.[NH:19]1[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)=[O:25])[CH2:20]1>>[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH3:10])[C:6]([C:11]2([OH:18])[CH2:16][CH2:15][CH:14]([N:19]3[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:36])[F:37])[CH:30]=4)=[O:25])[CH2:20]3)[CH2:13][CH2:12]2)=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361620HCID 59361620, compound

Product 1

HCID 46240485HCID 46240485, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-(2,4-dimethoxy-pyrimidin-5-yl)-4-hydroxy-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-b77db3ea1f664c448539e093fca19f3a
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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