HCID 46240379, compound → HCID 46240381, compound

Participants

Reaction Steps

N-({1-[4-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide 31a (100 mg, 0.18 mmol) in MeOH (25 mL) was passed through a 10% Pd on C cartridge in a H-Cube® Continuous-flow Hydrogenation reactor (ThalesNano, Budapest, Hungary) under full hydrogen mode (flow rate 1 mL/min). The resulting solution was concentrated to give the title compound as a yellow solid.

Provenance & Evidence