N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46240583, compound

HRID 2096188Notes

Reaction equation

HRID 2096188 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([C:9]3([OH:16])[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1.[NH:19]1[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)=[O:25])[CH2:20]1>>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([C:9]3([OH:16])[CH2:14][CH2:13][CH:12]([N:19]4[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]5[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:36])[F:37])[CH:30]=5)=[O:25])[CH2:20]4)[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361600HCID 59361600, compound

Product 1

HCID 46240583HCID 46240583, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-(6-Bromo-benzothiazol-2-yl)-4-hydroxy-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-8adfe002001f4ed08b05fdfc84652399
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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