HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone → N-({1-[4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone | HCID 59361558 | — |
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide | HCID 59361594 | — |
| Product | N-({1-[4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide | HCID 46240785 | — |
Reaction Steps
The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-(2-ethyl-thiazol-5-yl)-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450304B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-1007086b755f40bdb482cb18dc3bf3ae |
| Source note | uspto-grants-2013_05 |