N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46240784, compound

HRID 2096207Notes

Reaction equation

HRID 2096207 reaction equation
[OH:1][C:2]1([C:9]2[S:13][C:12]([S:14]([CH3:17])(=[O:16])=[O:15])=[N:11][CH:10]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[OH:1][C:2]1([C:9]2[S:13][C:12]([S:14]([CH3:17])(=[O:16])=[O:15])=[N:11][CH:10]=2)[CH2:7][CH2:6][CH:5]([N:18]2[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=3)=[O:24])[CH2:19]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 67425261HCID 67425261, compound

Product 1

HCID 46240784HCID 46240784, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-(2-methanesulfonyl-thiazol-5-yl)-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-b0882d0c429a45a5a801c012637e029d
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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