1,4-Dioxaspiro[4.5]decan-8-one → [5-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-thiazol-2-yl]-carbamic acid tert-butyl ester

HRID 2096209Notes

Reaction equation

HRID 2096209 reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][C:8]1[S:9][CH:10]=[CH:11][N:12]=1)([CH3:4])([CH3:3])[CH3:2].[O:14]1[C:18]2([CH2:23][CH2:22][C:21](=[O:24])[CH2:20][CH2:19]2)[O:17][CH2:16][CH2:15]1>>[C:1]([O:5][C:6](=[O:13])[NH:7][C:8]1[S:9][C:10]([C:21]2([OH:24])[CH2:22][CH2:23][C:18]3([O:17][CH2:16][CH2:15][O:14]3)[CH2:19][CH2:20]2)=[CH:11][N:12]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 11858898tert-butyl N-(1,3-thiazol-2-yl)carbamate

Product 1

HCID 59361624[5-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-thiazol-2-yl]-carbamic acid tert-butyl ester

Procedure

The title compound was prepared as a white solid from thiazol-2-yl-carbamic acid tert-butyl ester (prepared according to Das, B. et al. Tetrahedron Lett. 2006, 47, 7551-7556) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 33.

Sources & evidence

ORD record
ord-f2a265af29ae4d268b59b66eb2d2b0e3
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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