N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 59361630, compound

HRID 2096210Notes

Reaction equation

HRID 2096210 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[S:9][C:10]([C:13]2([OH:20])[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]2)=[CH:11][N:12]=1)([CH3:4])([CH3:3])[CH3:2].[NH:22]1[CH2:25][CH:24]([NH:26][C:27]([CH2:29][NH:30][C:31](=[O:42])[C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=2)=[O:28])[CH2:23]1>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[S:9][C:10]([C:13]2([OH:20])[CH2:18][CH2:17][CH:16]([N:22]3[CH2:25][CH:24]([NH:26][C:27](=[O:28])[CH2:29][NH:30][C:31](=[O:42])[C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:40])([F:41])[F:39])[CH:33]=4)[CH2:23]3)[CH2:15][CH2:14]2)=[CH:11][N:12]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361636HCID 59361636, compound

Product 1

HCID 59361630HCID 59361630, compound

Procedure

The title compounds were prepared as white solids from reductive amination of [5-(1-Hydroxy-4-oxo-cyclohexyl)-thiazol-2-yl]-carbamic acid tert-butyl ester, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-f83ded3c5b5a408f87a54a0a323d6306
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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