HCID 46240784, compound → HCID 46241010, compound

HRID 2096215Notes

Reaction equation

HRID 2096215 reaction equation
[OH:1][C:2]1([C:29]2[S:33][C:32](S(C)(=O)=O)=[N:31][CH:30]=2)[CH2:7][CH2:6][CH:5]([N:8]2[CH2:11][CH:10]([NH:12][C:13]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)=[O:14])[CH2:9]2)[CH2:4][CH2:3]1.[CH:38]([O:41][Na])([CH3:40])[CH3:39]>>[OH:1][C:2]1([C:29]2[S:33][C:32]([O:41][CH:38]([CH3:40])[CH3:39])=[N:31][CH:30]=2)[CH2:7][CH2:6][CH:5]([N:8]2[CH2:11][CH:10]([NH:12][C:13]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:25])[F:27])[CH:19]=3)=[O:14])[CH2:9]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 46240784HCID 46240784, compoundHCID 178459997HCID 178459997, compound

Product 1

HCID 46241010HCID 46241010, compound

Procedure

The title compound was prepared as a white solid from N-({1-[4-hydroxy-4-(2-methanesulfonyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide (less polar isomer, 47a),and i-PrONa (prepared in situ from IPA and 95% NaH) using the procedure described in Example 52.

Sources & evidence

ORD record
ord-05854c37e03849bd97db2ac0176a8377
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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