N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46241119, compound

HRID 2096226Notes

Reaction equation

HRID 2096226 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7]2([OH:14])[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[S:5][CH:6]=1.[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:35])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=2)=[O:21])[CH2:16]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:7]2([OH:14])[CH2:12][CH2:11][CH:10]([N:15]3[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=4)=[O:21])[CH2:16]3)[CH2:9][CH2:8]2)[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361609HCID 59361609, compound

Product 1

HCID 46241119HCID 46241119, compound

Procedure

The title compound was prepared as a white solid from reductive amination of 4-(4-bromo-thiophen-2-yl)-4-hydroxy-cyclohexanone, as prepared in the previous step, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-3a12fdc8b1c54b99a59b7f6e3e604232
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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