HCID 59361623, compound → HCID 46241220, compound

HRID 2096231Notes

Reaction equation

HRID 2096231 reaction equation
[OH:1][C:2]1([C:9]2[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:37])[C:26]2[CH:31]=[C:30]([F:32])[CH:29]=[C:28]([C:33]([F:36])([F:35])[F:34])[CH:27]=2)=[O:22])[CH2:17]1>>[F:32][C:30]1[CH:31]=[C:26]([CH:27]=[C:28]([C:33]([F:36])([F:34])[F:35])[CH:29]=1)[C:25]([NH:24][CH2:23][C:21](=[O:22])[NH:20][CH:18]1[CH2:19][N:16]([CH:5]2[CH2:6][CH2:7][C:2]([OH:1])([C:9]3[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=3)[CH2:3][CH2:4]2)[CH2:17]1)=[O:37]

Participants

3

Reactant 2

HCID 59361623HCID 59361623, compoundHCID 59361627HCID 59361627, compound

Product 1

HCID 46241220HCID 46241220, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-(6-methyl-pyridin-3-yl)-cyclohexanone, as prepared in Example 13 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-5-fluoro-benzamide, as prepared in the previous step, using the procedure described in Step E of Example 1.

Workup

  1. customas prepared in the previous step

Sources & evidence

ORD record
ord-8a6fe3ebe57446748ef726f64199cf33
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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