4-Hydroxy-4-(thiazol-5-yl)cyclohexanone → HCID 46241222, compound

HRID 2096232Notes

Reaction equation

HRID 2096232 reaction equation
[OH:1][C:2]1([C:9]2[S:13][CH:12]=[N:11][CH:10]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:14]1[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:35])[C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=2)=[O:20])[CH2:15]1>>[F:30][C:28]1[CH:29]=[C:24]([CH:25]=[C:26]([C:31]([F:34])([F:32])[F:33])[CH:27]=1)[C:23]([NH:22][CH2:21][C:19](=[O:20])[NH:18][CH:16]1[CH2:17][N:14]([CH:5]2[CH2:6][CH2:7][C:2]([OH:1])([C:9]3[S:13][CH:12]=[N:11][CH:10]=3)[CH2:3][CH2:4]2)[CH2:15]1)=[O:35]

Participants

3

Reactant 2

HCID 590174394-Hydroxy-4-(thiazol-5-yl)cyclohexanoneHCID 59361623HCID 59361623, compound

Product 1

HCID 46241222HCID 46241222, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-thiazol-5-yl-cyclohexanone, as prepared in Example 40 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-5-fluoro-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-5b7dee66400849198ba89814e62b9277
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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