HCID 59361627, compound → HCID 59361572, compound

HRID 2096235Notes

Reaction equation

HRID 2096235 reaction equation
[OH:1][C:2]1([C:9]2[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:40])[C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[C:28]([C:36]([F:39])([F:38])[F:37])[CH:27]=2)=[O:22])[CH2:17]1>>[OH:1][C:2]1([C:9]2[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH2:7][CH2:6][CH:5]([N:16]2[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:40])[C:26]3[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[C:28]([C:36]([F:37])([F:39])[F:38])[CH:27]=3)=[O:22])[CH2:17]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 59361627HCID 59361627, compoundHCID 59361640HCID 59361640, compound

Product 1

HCID 59361572HCID 59361572, compound

Procedure

The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-(6-methyl-pyridin-3-yl)-cyclohexanone, as prepared in Example 13 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-3,5-bis-trifluoromethyl-benzamide as prepared in the previous step, using the procedure described in Step E of Example 1.

Workup

  1. customas prepared in the previous step

Sources & evidence

ORD record
ord-3d70c4e6af654012a07eabe87ae5f94f
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

Loading…