HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 49784830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (1H-Pyrrolo[2,3-b]pyridin-1-yl)acetic acid | HCID 22139374 | — |
| Reactant | HCID 59564419 | HCID 59564419 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 49784830 | HCID 49784830 | 71% |
Reaction Steps
To 2-methoxy-5-(2-piperazin-1-yl-phenyl)-pyrimidine (7.4 g, 27.37 mmol) dissolved in dichloromethane (100 mL) is added pyrrolo[2,3-b]pyridin-1-yl-acetic acid (4.82 g, 27.37 mmol), TBTU (8.79 g, 27.37 mmol), and DIPEA (14.66 mL, 82.12 mmol). The reaction is stirred for 16 h at ambient temperature. The product is purified on a 100 g Biotage SNAP column with 40% EtOAc in hexanes to provide the title compound (8.3 g, 19.37 mmol, 71% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450317B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-4eff9712e0614666a6a0aae2df1d8796 |
| Source note | uspto-grants-2013_05 |