p-Toluenesulfonic acid → HCID 59564416, compound

Participants

Reaction Conditions

Reaction Steps

The N-(2-amino-phenyl)-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-benzamide (0.050 g, 0.116 mmol) is dissolved into 2 mL of dichloroethane and placed in a microwave tube. To this is added a catalytic amt. of p-TsOH. The mixture is heated in a microwave at 130° C. for 20 min and then 160° C. for 30 min. The reaction mixture is concentrated to dryness and the product is purified using a Gilson Prep HPLC system eluting with 20%-100% CH3CN/H2O) to give 43 mg of desired product. Impure fractions are concentrated and purified using a SiO2 prep plate eluting with (5% MeOH/CH2Cl2) to give an additional 17.5 mg of 1-{4-[2-(1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)-ethanone.

Provenance & Evidence