Tetrahydrofuran → HCID 59564353, compound

Participants

Reaction Steps

To a solution of 2-(3,5-dimethyl-pyrazol-1-yl)-1-{4-[2-(2-methylsulfanyl-pyrimidin-5-yl)-phenyl]-piperazin-1-yl}-ethanone (210 mg, 0.497 mmol) in THF (5 mL) is added a solution of oxone (611 mg, 0.994 mmol) in water (5 mL). The mixture is allowed to stir at room temperature for 4 h. Water (10 mL) is added and the mixture is extracted with EtOAc 3×. The organic extracts are washed with water, brine, dried (Na2SO4) and concentrated. The residue is re-dissolved in dichloromethane (3 mL) and loaded on a 10 g Biotage SNAP column and eluted with 100% EtOAc to provide 2-(3,5-dimethyl-pyrazol-1-yl)-1-{4-[2-(2-methanesulfonyl-pyrimidin-5-yl)-phenyl]-piperazin-1-yl}-ethanone (102 mg).

Provenance & Evidence