Methylamine → HCID 59564571, compound

Participants

Reaction Steps

The above sulfone (40 mg, 0.088 mmol) is added to a 0.5-2 mL Biotage microwave tube followed by methylamine (2M in THF, 0.22 mL, 0.44 mmol), Hunig's base (0.045 mL, 0.264 mmol) and isopropanol (1 mL). The reaction is carried out in a microwave oven at 175° C. for 15 min. After cooling, the mixture is filtered and purified via prep-HPLC. Removal of the solvent gives the title compound as colorless foam (15 mg).

Provenance & Evidence