HCID 54575307, compound → HCID 54575426, compound

Participants

Reaction Steps

To a solution of EXAMPLE 14 (180 mg, 0.47 mmol) in methanol (20 ml) was added Raney nickel (20 mg). The mixture was stirred at room temperature under hydrogen overnight. Methanol (100 ml) was added and the mixture was heated until all solid material went into solution. The Raney nickel was filtered off, and the filtrate was concentrated to afford the title compound. MS (DCI/NH3) m/z 356 (M+H)+; 1H NMR (300 MHz, dimethylsulfoxide-d6) δ 4.04 (s, 2H), 6.44 (d, J=5.42 Hz, 1H), 6.64 (d, J=7.46 Hz, 1H), 6.74 (s, 1H), 6.86 (d, J=7.46 Hz, 1H), 7.07-7.21 (m, 2H), 7.27 (s, 1H), 7.60 (s, 1H), 7.81 (d, J=2.03 Hz, 1H), 8.12 (d, J=7.80 Hz, 1H), 8.24 (d, J=3.73 Hz, 1H), 10.50 (d, J=5.42 Hz, 1H), 11.73 (s, 1H).

Provenance & Evidence