Sodium Acetate → HCID 67440378, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of EXAMPLE 37B (21.0 g, 34 mmol) in N,N-dimethylformamide (900 ml) was added sodium acetate (2.81 g, 34 mmol), tetrabutyl ammonium chloride (9.51 g, 34 mmol) and palladium(II) acetate (767 mg, 3.4 mmol). The mixture was heated at 120° C. for 30 minutes. After cooling, the reaction mixture was partitioned between ethyl acetate and brine. The organic phase was washed with water, and concentrated. The residue was purified by flash chromatography (50% ethyl acetate in hexane) to afford the title compound. LC-MS (ESI): m/z 616, 618 (M, M+2), RT: 2.38 minutes.

Provenance & Evidence