HCID 67440895, compound → HCID 54575607, compound

Participants

Reaction Steps

A solution of EXAMPLE 44A (25 mg, 0.04 mmol) in trifluoroacetic acid (2 ml) was stirred at 50° C. for 3 hours. The reaction mixture was then concentrated, and the residue was purified by HPLC (0-100% gradient acetonitrile in water containing 0.1% trifluoroacetic acid) to afford the title compound. MS (DCI/NH3) m/z 467 (M+H)+; 1H NMR (300 MHz, dimethylsulfoxide-d6): δ 1.11-1.54 (m, 4H), 1.55-1.89 (m, 4H), 2.91-3.09 (m, 2H), 4.12 (d, J=4.41 Hz, 2H), 4.18 (s, 2H), 6.52 (d, J=5.76 Hz, 1H), 7.15 (dd, J=7.80, 4.75 Hz, 1H), 7.28 (d, J=1.70 Hz, 1H), 7.45 (d, J=8.81 Hz, 2H), 7.55 (d, J=8.81 Hz, 2H), 7.67 (d, J=1.36 Hz, 1H), 7.83 (d, J=2.37 Hz, 1H), 8.13 (d, J=7.80 Hz, 1H), 8.24 (s, 1H) 10.57 (d, J=5.42 Hz, 1H), 11.76 (s, 1H).

Provenance & Evidence