反应详情

温度

70 °C

A mixture of 6-(2-(3-fluorophenyl)piperidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine (50 mg, 0.146 mmol) and SnCl2 dihydrate (165 mg, 0.732 mmol) in 5 mL EtOH was first stirred at 70° C. for 30 minutes, then cooled to ambient temperature and concentrated. EtOAc and water (10 mL each) were added to the solid residue, followed by Na2CO3 aqueous solution (2 mL×2 N) to obtain a phase break. The organic layer was separated, and the aqueous layer was extracted with EtOAc (3×10 mL). The combined organic layers was dried with Na2SO4 and concentrated to provide the product for the next step.

1. temperaturecooled to ambient temperature
2. concentrationconcentrated
3. additionEtOAc and water (10 mL each) were added to the solid residue
4. customto obtain a phase break
5. customThe organic layer was separated
6. extractionthe aqueous layer was extracted with EtOAc (3×10 mL)
7. dry with materialThe combined organic layers was dried with Na2SO4
8. concentrationconcentrated
9. customto provide the product for the next step