3-Fluorophenylboronic acid → HCID 59252462, compound

HRID 2096331Notes

Reaction equation

HRID 2096331 reaction equation
[C:1]1([C:7]2[N:12]=[CH:11][C:10]([C:13]3[N:14]=[C:15]([CH:18]4[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]4)[NH:16][CH:17]=3)=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B(O)(O)C1C=CC=C(F)C=1>>[C:1]1([C:7]2[N:12]=[CH:11][C:10]([C:13]3[NH:14][C:15]([CH:18]4[CH2:22][CH2:21][NH:20][CH2:19]4)=[N:16][CH:17]=3)=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 178451798HCID 178451798, compound

Product 1

HCID 59252462HCID 59252462, compound

Procedure

The title compound was prepared according to the method described in Example 22, except that (±)-tert-butyl 3-(4-(2-phenylpyrimidin-5-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (Example 28) was used instead of (±)-tert-butyl 3-(4-(2-phenylpyrimidin-5-yl)-1H-imidazol-2-yl)piperidine-1-carboxylate. MS (ESI+) m/z 292 (M+1); H-PGDS FPBA IC50: 2 μM.

Sources & evidence

ORD record
ord-9514a02be5214b8e92df6b17160a7940
Source dataset
uspto-grants-2013_05
Patent number
US08450326B2

Reaction notes

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