HCID 59252406, compound → HCID 59252427, compound

HRID 2096337Notes

Reaction equation

HRID 2096337 reaction equation
C([N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:11][N:10]=[C:9]1[C:19]1[CH:20]=[N:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[N:23][CH:24]=1)C1C=CC=CC=1.C(N1C(C2C=NC(C3C=CC=CC=3)=NC=2)=CN=C1C1C=CC=CC=1)C1C=CC=CC=1>>[C:25]1([C:22]2[N:21]=[CH:20][C:19]([C:9]3[NH:8][C:12]([C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=4)=[CH:11][N:10]=3)=[CH:24][N:23]=2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 59252406HCID 59252406, compoundHCID 592524685-(1-benzyl-2-phenyl-1H-imidazol-5-yl)-2-phenylpyrimidine

Product 1

HCID 59252427HCID 59252427, compound

Procedure

The title compound was prepared by the method described in Example 1, Step D, except that 5-(1-benzyl-5-phenyl-1H-imidazol-2-yl)-2-phenylpyrimidine (this Example, Step B) was used instead of 5-(1-benzyl-2-phenyl-1H-imidazol-5-yl)-2-phenylpyrimidine. The title compound was isolated as a white solid (0.044 g, 62% yield); Rf 0.26 with 95:5 v/v dichloromethane-methanol; melting point 238° C.; 1H-NMR (400 MHz; DMSO-d6) δ 9.40 (s, 2H), 8.43 (m, 2H), 7.99-7.84 (m, 2H), 7.58-7.20 (m, 8H); MS (ESI+) m/z 299.1 (M+1); H-PGDS FPBA IC50: 2.8 μM.

Workup

  1. customThe title compound was prepared by the method

Sources & evidence

ORD record
ord-28d0d9fe33a94420b529df634a0487ad
Source dataset
uspto-grants-2013_05
Patent number
US08450326B2

Reaction notes

Loading…