HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 7-Methyl-2,3-dihydrobenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 7-Methyl-2,3-dihydro-1-benzofuran-3-ol | HCID 13013060 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 7-Methyl-2,3-dihydrobenzofuran | HCID 22592386 | — |
Reaction Steps
Under a nitrogen atmosphere 0.610 g (4.06 mmol) 7-methyl-2,3-dihydro-benzofuran-3-ol in 5 mL acetic acid were refluxed with 770 μL. (8.16 mmol) acetic anhydride for 2 h. After cooling to RT, 60 mg palladium on charcoal (Pd/C 10%) were added and the mixture was hydrogenated for 3.5 h under a hydrogen atmosphere (3 bar). The catalyst was filtered off and the solvent was evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450327B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-1d07bedb145f49839c6aebd96fa77c34 |
| Source note | uspto-grants-2013_05 |