Benzenesulfonic Acid → HCID 58346321, compound

Participants

Reaction Steps

144 mg (0.500 mmol) 6-(6-chloropyrimidine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one, 126 mg (0.500 mmol) 5-amino-1,3-dihydrospiro[inden-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one and 16.1 mg (0.100 mmol) benzenesulphonic acid were combined in 5.0 mL 2-pentanol and refluxed for 4 h. The reaction mixture was evaporated down, the residue was triturated with PE, suction filtered and washed with PE. The residue was purified by preparative HPLC, the fractions containing the product were combined and the organic solvent was eliminated i.vac. The aqueous phase was neutralised by the addition of 1N aqueous NaOH solution. The product precipitated as a solid was filtered off, washed with water and dried.

Provenance & Evidence