Diisopropylethylamine → HCID 25265434, compound

Participants

Reaction Steps

102 mg (0.400 mmol) spiro[benzo[d][1,3]oxazin-4,4′-piperidin]-2(1H)-on hydrochloride, 122 mg (0.400 mmol) 6-(6-chloropyrimidin-4-carbonyl)-4-methyl-3H-benzoxazol-2-one and 0.210 mL (1.20 mmol) DIPEA were combined in 3.0 mL DMF and stirred for 48 h. The mixture was purified by preparative HPLC-MS. The fractions containing the product were combined, the organic solvent was eliminated i.vac. and the aqueous phase remaining was neutralised with 4M aqueous NaOH solution. The product precipitated as a solid was suction filtered, washed with water and dried in the CAD.

Provenance & Evidence