HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 25265435, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-(6-chloropyrimidine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one | HCID 58181162 | — |
| Reactant | Spiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazin]-2'(1'H)-one hydrochloride | HCID 66687106 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25265435 | HCID 25265435 | — |
Reaction Steps
55 mg (0.21 mmol) spiro[piperidin-4,4′-pyrido[2.3-d][1,3]oxazin]-2′(1′H)-one hydrochloride, 65 mg (0.21 mmol) 6-(6-chloropyrimidin-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one and 0.15 mL (0.84 mmol) DIPEA were combined in 1.8 mL DMF and stirred overnight at RT. Then the reaction mixture was purified by preparative HPLC-MS. The fractions containing the product were combined and freeze-dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450327B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e48895e7a0044bd5837d30383b9834b7 |
| Source note | uspto-grants-2013_05 |