3-Vinylphenylboronic Acid (contains varying amounts of Anhydride) → 2'-amino-1'-methyl-2-phenyl-6-(3-vinylphenyl)spiro[chroman-4,4'-imidazol]-5'(1'H)-one

Participants

Reaction Conditions

Reaction Steps

Pd(PPh3)2Cl2 (15 mg) in a 10 mL tube under Ar was treated sequentially with 2′-amino-6-bromo-1′-methyl-2-phenylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (50 mg, 0.13 mmol) in 1,4-dioxane (2 mL), Cs2CO3 (2 N, 0.6 mL) and 3-vinylphenylboronic acid (29 mg, 0.19 mmol). The mixture was heated at 120° C. under microwave reactor for 0.5 h. The reaction mixture was concentrated in vacuo to give the residue, which was purified by preparative TLC to give pure 2′-amino-1′-methyl-2-phenyl-6-(3-vinylphenyl)spiro[chroman-4,4′-imidazol]-5′(1′H)-one (3 mg, 6%). 1H-NMR (MeOD): 1.40 (s, 9H), 2.44 (m, 1H), 2.61 (m, 1H), 3.25 (s, 3H), 5.85 (d, 1H), 6.14 (m, 1H), 6.23 (m, 1H), 7.05 (m, 1H), 7.16 (m, 1H), 7.32 (m, 2H), 7.49 (m, 5H).

Provenance & Evidence