Ammonium iodide → HCID 58424154, compound

Participants

Reaction Steps

A solution of 6-bromo-2-(3-fluorophenyl)-1′-methyl-2′-(methylthio)spiro[chroman-4,4′-imidazol]-5′(1′H)-one (80 mg, 0.18 mmol) and NH4I (52 mg, 0.36 mmol) in NH3/EtOH (4 mL, 1.5 N) was heated at 110° C. in a tube in a microwave reactor for 2-2.5 h. After cooling, the mixture was concentrated in vacuo to give a residue, which was purified by preparative TLC and then by preparative HPLC to afford 2′-amino-6-bromo-2-(3-fluorophenyl)-1′-methylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (36 mg, 50%). 1H-NMR (MeOD): 2.16 (m, 2H), 3.12 (s, 3H), 5.87 (d, 1H), 6.90 (d, 1H), 7.08 (m, 2H), 7.25 (m, 2H), 7.33 (d, 1H), 7.41 (m, 1H).

Provenance & Evidence