HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2096520Generated: October 31, 2026
Sodium Carbonate → 7-Fluoro-6-(2-fluoropyridin-3-yl)-2-phenylchroman-4-one
https://huagongshe.com/reaction/2096520
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| Reactant | 6-Bromo-7-fluoro-2-phenylchroman-4-one | HCID 58424001 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Toluene ethanol | HCID 21863594 | — |
| Product | 7-Fluoro-6-(2-fluoropyridin-3-yl)-2-phenylchroman-4-one | HCID 58424017 | 23.3% |
Reaction Steps
A mixture of 6-bromo-7-fluoro-2-phenylchroman-4-one (318 mg, 0.994 mmol), 2-fluoropyridin-3-ylboronic acid (210 mg, 1.5 mmol), Na2CO3 (318 mg, 2.98 mmol), PPh3 (34 mg) and Pd(PPh3)2Cl2 (59 mg, 0.1 mmol) in toluene/EtOH (v/v=1/1, 10.5 mL) was degassed and stirred at 110° C. for 20 minutes. The reaction mixture was concentrated in vacuo to give the residue, which was purified by preparative TLC to give 7-fluoro-6-(2-fluoropyridin-3-yl)-2-phenylchroman-4-one (78 mg, 23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08450308B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-73eb9d024a424c4189a4180dc3b7e2bf |
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| Source note | uspto-grants-2013_05 |
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