Bis(trimethylsilyl)carbodiimide → HCID 178430619, compound

HRID 2096543Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][CH:16]=1)[O:13][C:7]1([CH2:12][CH2:11][CH2:10][O:9][CH2:8]1)[CH:6]([CH3:17])[C:5]2=O.C[Si]([N:23]=[C:24]=[N:25][Si](C)(C)C)(C)C>C(Cl)Cl.Cl[Ti](Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][CH:16]=1)[O:13][C:7]1([CH2:12][CH2:11][CH2:10][O:9][CH2:8]1)[CH:6]([CH3:17])/[C:5]/2=[N:25]\[C:24]#[N:23]

Participants

Conditions

Temperature: 65 °C

Procedure

A solution of 6-bromo-3-methyl-2′,4′,5′,6′-tetrahydrospiro[chroman-2,3′-pyran]-4-one (200 mg, 0.65 mmol) and TiCl4 (864 mg, 4.55 mmol) in anhydrous DCM (8 mL) was heated at 50° C. under microwave for 5 mins. Then bis-trimethylsilylcarbodiimide (360 mg, 1.95 mmol) was added and the mixture was heated at 65° C. for another 1 hr. The reaction mixture was poured into ice-water and extracted with DCM. The combined organic phases were dried over anhydrous Na2SO4, filtered and concentrated to give (E)-N-(6-bromo-3-methyl-2′,4′,5′,6′-tetrahydrospiro[chroman-2,3′-pyran]-4-ylidene)cyanamide (300 mg, crude), which was used in the next step without further purification.

Workup

extractionextracted with DCM
dry with materialThe combined organic phases were dried over anhydrous Na2SO4
filtrationfiltered
concentrationconcentrated

Sources & evidence

ORD record: ord-48da5757b6d142f79a1450e3fe47095b
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08450308B2

Reaction notes

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