HCID 86657450, compound → HCID 86657449, compound

Participants

Reaction Steps

To a solution of 3-(2-amino-1-methyl-5-oxo-2′-phenyl-1,5-dihydrospiro[imidazole-4,4′-thiochroman]-6′-yl)benzonitrile TFA salt (27 mg, 0.05 mmol) in MeOH (5 mL) and H2O (0.1 mL) is added NaIO4 (21.4 mg, 0.10 mmol). The resulting mixture is stirred overnight at rt, then purified by preparative HPLC to give 3-(2-amino-1-methyl-1′,5-dioxo-2′-phenyl-1,5-dihydrospiro[imidazole-4,4′-thiochroman]-6′-yl)benzonitrile TFA salt (16 mg) with 5 mg of recovered starting material. MS ESI +ve m/z 441 (M+H)+.

Provenance & Evidence