HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2096623Generated: November 1, 2026
Sodium Hydroxide → 3-(2'-amino-2-phenyl-5'H-spiro[chroman-4,4'-thiazole]-6-yl)benzamide
https://huagongshe.com/reaction/2096623
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(2'-(tert-butylamino)-2-phenyl-5'H-spiro[chroman-4,4'-thiazole]-6-yl)benzonitrile | HCID 67174627 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-(2'-amino-2-phenyl-5'H-spiro[chroman-4,4'-thiazole]-6-yl)benzamide | HCID 58424410 | 73% |
Reaction Steps
A mixture of 3-(2′-(tert-butylamino)-2-phenyl-5′H-spiro[chroman-4,4′-thiazole]-6-yl)benzonitrile (30 mg, 0.066 mmol) in concentrated HCl (5 mL) was stirred at 100° C. for 2 h. Aqueous NaOH (6 N) was added until pH=8. The mixture was extracted with EtOAc and the organic layer was dried and concentrated to give the residue, which was purified by preparative TLC to give 3-(2′-amino-2-phenyl-5′H-spiro[chroman-4,4′-thiazole]-6-yl)benzamide (20 mg, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08450308B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-84a0c8e2e7fb4e18a5692c058198071a |
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| Source note | uspto-grants-2013_05 |
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