HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → methyl 2-(4-amino-6-bromo-2-phenylchroman-4-yl)acetate HCl salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-(6-bromo-4-(1,1-dimethylethylsulfinamido)-2-phenylchroman-4-yl)acetate | HCID 67173575 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | methyl 2-(4-amino-6-bromo-2-phenylchroman-4-yl)acetate HCl salt | HCID 67174352 | — |
Reaction Steps
A solution of methyl 2-(6-bromo-4-(1,1-dimethylethylsulfmamido)-2-phenylchroman-4-yl)acetate (427 mg, 0.89 mmol) in MeOH (7 mL) and 4 M HCl solution in 1,4-dioxane (14 mL) is stirred at rt for 30 min. The solvent is removed under reduced pressure to give 418 mg methyl 2-(4-amino-6-bromo-2-phenylchroman-4-yl)acetate HCl salt as a white foam, which is used for next step without further purification. MS ESI +ve m/z 376 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450308B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-3681a88517c14ffb9fcf7a614f51068d |
| Source note | uspto-grants-2013_05 |