Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Bis(bromomethyl)pyridine → (S)-2-Bromomethyl-6-(tetrahydrofuran-3-yloxymethyl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Bis(bromomethyl)pyridine | HCID 603610 | — |
| 반응물 | (S)-(+)-3-Hydroxytetrahydrofuran | HCID 2733227 | — |
| 생성물 | (S)-2-Bromomethyl-6-(tetrahydrofuran-3-yloxymethyl)pyridine | HCID 66718357 | 24% |
반응 단계
Prepared from 2,6-bis(bromomethyl)pyridine and (S)-tetrahydrofuran-3-ol by the alkylation method described for the final step of Example 32 to give the title compound (24%); NMR δH (400 MHz, CDCl3) 7.70 (1H, t, J 7.5 Hz), 7.39 (1H, d, J 7.5 Hz), 7.34 (1H, d, J 7.5 Hz), 4.67-4.59 (2H, m), 4.52 (2H, s), 4.31-4.26 (1H, m) 3.98-3.81 (4H, m), 2.11-1.99 (2H, m); (M+H)+ 272, 274.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08450328B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-9077d0971097421f9341652d36f0ed47 |
| 출처 메모 | uspto-grants-2013_05 |