HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanone → HCID 66718361, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanone | HCID 7967 | — |
| Reactant | Pyridine, 2-bromo-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]- | HCID 11483477 | — |
| Product | HCID 66718361 | HCID 66718361 | 15% |
Reaction Steps
Prepared from 6-bromo-O-(tert-butyldimethylsilyl)-2-pyridinemethanol and cyclohexanone by the method described in Example 10 to give the title compound (0.49 g, 15%) as a yellow oil; NMR δH (400 MHz, CDCl3) 0.13 (6H, s), 0.96 (9H, s), 1.61-1.91 (10H, m), 4.82 (2H, s), 5.17 (1H, s), 7.21 (1H, dd, J 8.0 Hz, 1.0 Hz), 7.38 (1H, dd, J 7.5 Hz), 1.0 Hz), 7.71 (1H, t, J 7.5 Hz). TLC (Hex:EtOAc (9:1)) Rf=0.30**
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450328B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-150436c2f2a1404ca24f74b4ee0f47b7 |
| Source note | uspto-grants-2013_05 |