(3-Methoxyphenyl)boronic acid → HCID 44554834, compound

HRID 2096680Notes

Reaction equation

HRID 2096680 reaction equation
Cl[C:2]1[C:3]2[N:11]=[N:10][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]4([OH:23])[CH2:22][CH2:21][CH2:20]4)[N:14]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.[CH3:24][O:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[CH3:24][O:25][C:26]1[CH:31]=[C:30]([C:2]2[C:3]3[N:11]=[N:10][N:9]([CH2:12][C:13]4[CH:18]=[CH:17][CH:16]=[C:15]([C:19]5([OH:23])[CH2:22][CH2:21][CH2:20]5)[N:14]=4)[C:4]=3[N:5]=[C:6]([NH2:8])[N:7]=2)[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 86655319HCID 86655319, compound

Product 1

HCID 44554834HCID 44554834, compoundYield 16%

Procedure

Prepared from 7-chloro-3-{6-[1-hydroxy-1-cyclobutyl]pyridin-2-ylmethyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine and 3-methoxyphenylboronic acid by the method described in Example 7 to give the title compound (0.04 g, 16%).

Sources & evidence

ORD record
ord-939f9103e30a4ce5b2f02b3edccc3113
Source dataset
uspto-grants-2013_05
Patent number
US08450328B2

Reaction notes

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