Isopropylethanediol → HCID 66718421, compound

HRID 2096698Notes

Reaction equation

HRID 2096698 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][Br:10])[N:4]=1.[CH:11]([O:14][CH2:15][CH2:16][OH:17])([CH3:13])[CH3:12]>>[Br:10][CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:2][O:17][CH2:16][CH2:15][O:14][CH:11]([CH3:13])[CH3:12])[N:4]=1

Participants

3

Reactant 2

HCID 7996IsopropylethanediolHCID 6036102,6-Bis(bromomethyl)pyridine

Product 1

HCID 66718421HCID 66718421, compoundYield 28%

Procedure

Prepared from 2,6-bis(bromomethyl)pyridine and 2-(isopropyloxy)ethanol by the alkylation method described for the final step of Example 32 to give the title compound (28%); NMR δH (400 MHz, CDCl3) 7.69 (1H, t, J 7.5 Hz), 7.43 (1H, d, J 7.5 Hz), 7.33 (1H, d, J 7.5 Hz), 4.69 (2H, s), 4.53 (2H, s), 3.73-3.69 (2H, m), 3.68-3.58 (3H, m), 1.18 (6H, d, J 6.0 Hz); (M+H)+288, 290.

Sources & evidence

ORD record
ord-8d427578d2fa415790f6f9205e0f821c
Source dataset
uspto-grants-2013_05
Patent number
US08450328B2

Reaction notes

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