HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 6-[2-(4-Bromo-2-chloro-phenyl)-acetyl]-8-fluoro-4-methyl-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | (4-Bromo-2-chlorophenyl)acetic acid | HCID 53403617 | — |
| Reactant | HCID 66697398 | HCID 66697398 | — |
| Product | 6-[2-(4-Bromo-2-chloro-phenyl)-acetyl]-8-fluoro-4-methyl-4H-benzo[1,4]oxazin-3-one | HCID 66697260 | — |
Reaction Steps
In analogy to Example 1, step 1, (4-bromo-2-chloro-phenyl)-acetic acid was converted to the acid chloride and reacted with 8-fluoro-4-methyl-4H-benzo[1,4]oxazin-3-one in the presence of AlCl3 to give the title compound as a light-brown solid. MS (m/e, ISP neg. ion)=411.9 [M−H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450313B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-48225b84fb8b4578929e3fbd97f6b78e |
| Source note | uspto-grants-2013_05 |