HRID2096754

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7748

Ethyl bromoacetate

C4H7BrO2

HCID10796

Cesium carbonate

CCs2O3

结构：CC(c1ccc(-c2ccc(F)c(O)c2)cc1Cl)C(O)(c1cc(F)c2c(c1)N(C)C(=O)CO2)C(F)(F)F

HCID86645870

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)COc1cc(-c2ccc(C(C)C(O)(c3cc(F)c4c(c3)N(C)C(=O)CO4)C(F)(F)F)c(Cl)c2)ccc1F

HCID75240040

未命名化合物

PROCEDURE

实验过程

In analogy to Example 1, step 5, 6-[2-(3-chloro-4′-fluoro-3′-hydroxy-biphenyl-4-yl)-1-hydroxy-1-trifluoromethyl-propyl]-8-fluoro-4-methyl-4H-benzo[1,4]oxazin-3-one was reacted with ethylbromoacetate and cesium carbonate to give the title compound as a colorless foam. MS (m/e)=614.2 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2ca1f06219c41f9bb4b4791694ae315
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08450313B2
来源说明: uspto-grants-2013_05

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[C:31]([OH:36])[CH:30]=2)[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:28])[C:9]([C:15]1[CH:16]=[C:17]([F:27])[C:18]2[O:23][CH2:22][C:21](=[O:24])[N:20]([CH3:25])[C:19]=2[CH:26]=1)([OH:14])[C:10]([F:13])([F:12])[F:11].[CH2:37]([O:39][C:40](=[O:43])[CH2:41]Br)[CH3:38].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH2:37]([O:39][C:40](=[O:43])[CH2:41][O:36][C:31]1[CH:30]=[C:29]([C:4]2[CH:5]=[CH:6][C:7]([CH:8]([CH3:28])[C:9]([C:15]3[CH:16]=[C:17]([F:27])[C:18]4[O:23][CH2:22][C:21](=[O:24])[N:20]([CH3:25])[C:19]=4[CH:26]=3)([OH:14])[C:10]([F:13])([F:11])[F:12])=[C:2]([Cl:1])[CH:3]=2)[CH:34]=[CH:33][C:32]=1[F:35])[CH3:38]