Tetramethylammonium fluoride → HCID 86645871, compound

HRID 2096755Notes

Reaction equation

HRID 2096755 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:22])[C:9]([C:11]2[CH:12]=[CH:13][C:14](=[O:21])[N:15]3[C:20]=2[CH:19]=[CH:18][CH:17]=[CH:16]3)=[O:10])=[C:4]([Cl:23])[CH:3]=1.[F:24][C:25]([Si](C)(C)C)([F:27])[F:26].[F-].C[N+](C)(C)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:22])[C:9]([C:11]2[CH:12]=[CH:13][C:14](=[O:21])[N:15]3[C:20]=2[CH:19]=[CH:18][CH:17]=[CH:16]3)([OH:10])[C:25]([F:27])([F:26])[F:24])=[C:4]([Cl:23])[CH:3]=1

Participants

4

Reactant 3

HCID 67803Tetramethylammonium fluorideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 86645872HCID 86645872, compound

Product 1

HCID 86645871HCID 86645871, compound

Procedure

In analogy to Example 1, step 3, 1-[2-(4-bromo-2-chloro-phenyl)-propionyl]-quinolizin-4-one was reacted with (trifluoromethyl)trimethylsilane and tetramethylammonium fluoride to give the title compound as a light yellow solid. MS (m/e)=460.2 [M+H+].

Sources & evidence

ORD record
ord-9d7c7180f7bf4c1bb50b62712e62206c
Source dataset
uspto-grants-2013_05
Patent number
US08450313B2

Reaction notes

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