3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → HCID 75240042, compound

HRID 2096756Notes

Reaction equation

HRID 2096756 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:26])[C:9]([C:15]2[CH:16]=[CH:17][C:18](=[O:25])[N:19]3[C:24]=2[CH:23]=[CH:22][CH:21]=[CH:20]3)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:27])[CH:3]=1.[F:28][C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=1[C:35]([O:37][CH3:38])=[O:36]>>[CH3:38][O:37][C:35]([C:34]1[CH:33]=[CH:32][C:31]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([CH3:26])[C:9]([OH:14])([C:15]3[CH:16]=[CH:17][C:18](=[O:25])[N:19]4[C:24]=3[CH:23]=[CH:22][CH:21]=[CH:20]4)[C:10]([F:11])([F:13])[F:12])=[C:4]([Cl:27])[CH:3]=2)=[CH:30][C:29]=1[F:28])=[O:36]

Participants

3

Reactant 2

HCID 27828183-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 86645871HCID 86645871, compound

Product 1

HCID 75240042HCID 75240042, compound

Procedure

In analogy to Example 17, step 2, 1-[2-(4-bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-quinolizin-4-one was reacted with 3-fluoro-4-methoxycarbonylphenylboronic acid to give the title compound as a light yellow solid. MS (m/e)=534.2 [M+H+].

Sources & evidence

ORD record
ord-3375d7aad3ae4bd5906877a4cc0e9e5c
Source dataset
uspto-grants-2013_05
Patent number
US08450313B2

Reaction notes

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